Lixoft Monolix Suite 2019 R1 x64-藥物學非線性混合效應建模計算
LixoftMonolix是基於藥物模型開發參考的平台。它結合了最先進的算法具有獨特的易用性。藥物計量
學家和生物統計學習可以依靠Monolix進行生物分析，並去模型PK/PD和其它複雜的生化和生理過程。Monolix是
一種簡單，快捷，功能強大的工具，適用於參數估計的非線性混合效應模型，模型診斷和評估，以及先進的圖形表示等。

Monolixisthemostadvancedandsimplesolutionfornon-linearmixedeffectsmodeling(NLME)forpharmacometrics.ItisbasedontheSAEMalgorithmandprovidesrobust,globalconvergenceevenforcomplexPK/PDmodels.MonolixisusedforpreclinicalandclinicalpopulationPK/PDmodelingandforSystemsPharmacology.Monolixenjoysalargeusercommunity.Monolixiswidelyusedbyacademia,thepharmaceuticalindustryaswellastheUSregulatoryagencies.

AdvancedStatisticalMethodologies
ReliableconvergenceforalltypeofdataisacenterpieceinpopulationPKPDmodeling,whichiswhyLixoftpioneeredincollaborationwithInriatheSAEMalgorithm.

Automatedgenerationofdiagnostictests
MonolixautomaticallygeneratesafullsetofdiagnosticplotsevenforcomplexPK/PDmodels.Forexample,youcaninstantaneouslycreatetheVisualPredictiveCheck,splitbyanypatientsubgroupyouwouldwanttoinvestigate.

Increasedproductivityandquality
EfficientC++solverpackage,standardizedmodellanguagewithMlxtran,PK/PDmodellibraryandintegratedsoftwareallcontributetobetterproductivityandquality.

VeryeasytousewithitsGUI
Oursolutionsaredesignedforeaseofuse.Monolixcanbeusedviaagraphicalinterfaceorcommandlinesforpowerfulscripting.Thismeanslessprogrammingforyouandmorefocusonexploringmodelsandpharmacologytodeliverintimetoyourcustomers.

Keyfeatures:
Supportofallrelevantdatatypesandstatisticalfeatures
MonolixcoversawiderangeofdatatypesandstatisticalfeaturesforpopulationPK/PDmodeling.Forallcasestherightstatisticalmethodologyhasbeendevelopedandpublishedforreference.

Monolixcovers:
Continuous,categorical,countandrepeatedtimetoeventdata.
Mixturemodelsandmixturesofmodels.
Inter-occasionvariabilitywithanynumberoflevels.
ProperhandlingofBLQdata.
Normal,lognormal,logit,probitanduserdefineddistributionsfortheindividualparameters.